HAT (Hemorrhage After Thrombolysis) Score for Predicting Post-tPA Hemorrhage
Predicts the risk of post‑tPA intracerebral hemorrhage using NIHSS severity, CT hypodensity, baseline glucose, and diabetes history.
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사용 적응증
Used in adults with acute ischemic stroke receiving IV tPA to estimate early post‑tPA symptomatic ICH risk using NIHSS, baseline CT hypodensity, glucose, and diabetes history. Provides quick bedside stratification with moderate discrimination (c‑statistic ~0.72–0.74) and rising sICH rates from 2% to 44% across score tiers 1 [Level II evidence]. Supports post‑tPA monitoring intensity, not tPA eligibility decisions.
통찰 및 주의사항
Stratifies post‑tPA hemorrhage risk using NIHSS, baseline glucose, diabetes, and early CT hypodensity, with symptomatic ICH rising from 2% at 0 points to 44% at >3 points 1 [Level II evidence].
Cautions: Only moderate discrimination (c‑statistic ~0.72–0.74) 1 [Level II evidence]; later comparisons show no score reliably outperforms others or guides net tPA benefit 2 [Level II evidence].