Notizie mediche e ricerca

A federal initiative has launched two proof-of-concept oncology trials plus an RFI for a summer pilot, aiming to reduce phase-to-phase delays by enabling FDA review of validated trial signals as data accrue.

Phase 1 dose-escalation data for ZW191 reported cORR 78.6% in FRα-high and 47.4% in FRα-low/negative PROC, with median DoR not reached and grade 3 or higher TEAEs in 55%.

Dose–response network meta-analysis of 64 RCTs with 5156 women found combined training best for fatigue and lean mass and resistance training best for function and strength, with benefits seen from as little as 10–40 minutes per week.

Prospective cohort data suggest ~7 kg gain at 1 year and ~11 kg by 4 years, with 40–50% gaining at least 10%, and early 3-month gain tracking long-term trajectory—supporting risk stratification and proactive weight management.