Notizie mediche e ricerca

In a single-center retrospective cohort of 74,717 term singleton births using propensity-weighted intent-to-treat analysis, CDMR rates rose to 2.5% and were linked to a 60% lower postpartum hemorrhage risk but a 36% higher risk of hospitalization beyond 4 days, with no clear difference in NICU admission or respiratory morbidity.

In a prospective citywide NICU/PICU program of 100 patients, median turnaround was 3.4 days with 53% diagnostic yield and 53% management change, outperforming a matched historical cohort with 38-day turnaround and 30% yield.

In a multicenter retrospective cohort of 558,823 transfusions, allergic reactions were nearly 4-fold higher in US high-prevalence regions when type O patients received B or AB units vs O units, supporting targeted mitigation in these settings.

In a single-center observational cohort of 104 recipients, overall CHIP did not track with CRS or ICANS, but TP53-mutant CHIP correlated with baseline cytopenias, reduced CAR T expansion, and worse outcomes, supporting genotype-directed monitoring.