Medizinische Nachrichten und Forschung

In a single-center retrospective cohort of 1187 patients, overweight and obesity correlated with better survival, while CT phenotyping in 659 patients linked higher skeletal muscle to lower mortality and higher intermuscular fat to increased death risk.

In a 410-patient phase 3 double-blind RCT, 52 weeks of nicotinamide riboside increased MDS-UPDRS by 2.7 points relative to placebo and worsened nonmotor symptoms despite similar serious adverse event rates.

In a 2,623-patient PETHEMA real-world cohort, 68% had detectable MRD after 1 induction cycle, and MRD-negative status at the 0.01% cutoff independently correlated with overall survival, with weaker signal in some genetic risk and post-consolidation subgroups.

Approval is based on reduced daily cornstarch intake in patients aged 8 years and older, with continued authorization contingent on confirmatory evidence of clinical benefit.