NAFLD (Non-Alcohol Fatty Liver Disease) Activity Score

Steatosis (grade): low- to medium-power evaluation of parenchymal involvement by steatosis

Inflammation (lobular): overall assessment of all inflammatory foci

Liver cell injury (ballooning)

References

NA. EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD): Executive Summary.. Diabetologia, 2024
Mazen Noureddin. Serum identification of at-risk MASH: The metabolomics-advanced steatohepatitis fibrosis score (MASEF).. Hepatology (Baltimore, Md.), 2024
NA. EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD).. Journal of hepatology, 2024
Cheng Han Ng. Mortality Outcomes by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis.. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2023
F. Mózes. Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis.. The lancet. Gastroenterology & hepatology, 2023
Fasiha Kanwal. Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease.. Gastroenterology, 2021
Fasiha Kanwal. Preparing for the NASH Epidemic: A Call to Action.. Gastroenterology, 2021
R. Taylor. Association Between Fibrosis Stage and Outcomes of Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis.. Gastroenterology, 2020
P. Bedossa. Biopsy and Noninvasive Methods to Assess Progression of Nonalcoholic Fatty Liver Disease.. Gastroenterology, 2016
D. Kleiner. Liver histology and clinical trials for nonalcoholic steatohepatitis-perspectives from 2 pathologists.. Gastroenterology, 2015
Paul Angulo. Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease.. Gastroenterology, 2015
Elizabeth M Brunt. Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings.. Hepatology (Baltimore, Md.), 2011
D. Kleiner. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology, 2005