Mekhail Extension of the Motzer Score

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LDH > 1.5x upper limit of normal (normal: 140 U/L)

Hb < lower limit of normal (normal: < 12 g/dL (120 g/L)

Corrected serum calcium > 10 mg/dL (2.5 mmol/L)

Time from initial diagnosis to systemic treatment < 1 year

Prior treatment with radiation

≥ 2 sites of metastasis

References

T Powles. Renal cell carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.. Annals of oncology : official journal of the European Society for Medical Oncology, 2024
Robert J Motzer. Kidney Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.. Journal of the National Comprehensive Cancer Network : JNCCN, 2022
T. Mekhail. Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005
Reference - 10.1016/j.annonc.2024.05.537\
Reference - 10.1200/JCO.22.00868\